Kirana H, Srinivasan Bp
T.V.M. College of Pharmacy, Gandhinagar, Bellary-583103, Karnataka, India.
J Young Pharm. 2010 Jul;2(3):265-8. doi: 10.4103/0975-1483.66806.
Significant depletion of glutathione (GSH-reduced form) was observed in type 2 diabetes due to oxidative stress. Hence the present study was aimed to investigate a drug which restores GSH along with its anti-diabetic activity. Aqueous extract of Garcinia indica at a dose of 100 mg/kg and 200 mg/kg was given orally to streptozotocin-induced type 2 diabetic rats for a period of 4 weeks. At the end, parameters such as fasting blood glucose, postprandial blood glucose, and GSH in blood were analyzed. Aqueous extract of G. indica significantly decreased both the fasting and postprandial blood glucose in type 2 diabetic rats. The extract also restored the erythrocyte GSH in type 2 diabetic rats. Drug at higher dose, i.e. 200 mg/kg, had a more pronounced effect. Restoring the erythrocyte GSH, an intracellular anti-oxidant in diabetes, will be beneficial specially by preventing the risk of developing complications.
由于氧化应激，在2型糖尿病中观察到谷胱甘肽（还原型谷胱甘肽）显著消耗。因此，本研究旨在研究一种既能恢复谷胱甘肽又具有抗糖尿病活性的药物。将印度藤黄的水提取物以100mg/kg和200mg/kg的剂量口服给予链脲佐菌素诱导的2型糖尿病大鼠，持续4周。最后，分析了空腹血糖、餐后血糖和血液中谷胱甘肽等参数。印度藤黄的水提取物显著降低了2型糖尿病大鼠的空腹血糖和餐后血糖。该提取物还恢复了2型糖尿病大鼠红细胞中的谷胱甘肽。较高剂量（即200mg/kg）的药物具有更显著的效果。恢复糖尿病患者细胞内抗氧化剂红细胞谷胱甘肽，特别是通过预防并发症发生的风险将是有益的。
