Kirana H, Jali M V, Srinivasan B P
T.V.M. College of Pharmacy, Gandhi Nagar, Bellary-583 103, India.
Pharmacognosy Res. 2011 Jan;3(1):30-4. doi: 10.4103/0974-8490.79112.
Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats.
Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of F. religiosa at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed.
Aqueous extract of F. religiosa at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect.
Modulation of cytokine TNF-α by the aqueous extract of F. religiosa indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.
慢性全身炎症是2型糖尿病发病机制中的早期过程。因此，本研究旨在探讨传统上已知的植物菩提树对2型糖尿病大鼠血糖升高及炎症标志物肿瘤坏死因子（TNF）-α的影响。
在新生大鼠模型中腹腔注射链脲佐菌素（90mg/kg）诱导2型糖尿病。将菩提树水提取物以100和200mg/kg的剂量口服给予相应组别的动物，持续4周。药物治疗4周后，分析空腹血糖、餐后血糖和血清TNF-α等参数。
100和200mg/kg剂量水平的菩提树水提取物均降低了2型糖尿病大鼠升高的血糖和TNF-α。200mg/kg的提取物效果更显著。
菩提树水提取物对细胞因子TNF-α的调节表明，该植物的抗炎和免疫调节特性与其潜在的抗糖尿病活性有关。
