导肽的光化学切割。
Photochemical cleavage of leader peptides.
机构信息
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, IL 61801, USA.
出版信息
Chem Commun (Camb). 2010 Dec 21;46(47):8935-7. doi: 10.1039/c0cc02945a. Epub 2010 Nov 2.
Abstract
We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne-azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.
摘要
我们报道了一种光不稳定连接子，它与 Fmoc 固相肽合成和 Cu(I)催化的叠氮-炔环加成反应兼容，通过光化学裂解可以得到带有天然氨基末端的 C 末端肽片段。
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