腙键连接策略组装多功能病毒纳米颗粒用于细胞成像和肿瘤靶向。
Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting.
机构信息
Department of Cell Biology.
出版信息
Nano Lett. 2010 Mar 10;10(3):1093-7. doi: 10.1021/nl1002526.
Abstract
Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.
摘要
多价纳米颗粒平台因其改善的靶向特异性、灵敏度和溶解性而受到生物医学应用的青睐。然而，它们的可控组装仍然是一个相当大的挑战。一种有效的腙键连接化学被应用于具有可单独调节水平的 VEGFR-1 配体和荧光 PEG 化肽的豇豆花叶病毒 (CPMV) 纳米颗粒的组装。这些纳米颗粒识别内皮细胞系和小鼠中 VEGFR1 表达的肿瘤异种移植物上的 VEGFR-1，验证了靶向 CPMV 作为体内纳米颗粒平台的有效性。
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