National Institute for Occupational Safety and Health, National Personal Protective, Technology Laboratory, Pittsburgh, PA 15236, USA.
J Appl Microbiol. 2011 Jan;110(1):287-95. doi: 10.1111/j.1365-2672.2010.04881.x. Epub 2010 Nov 4.
To develop a method to assess model-specific parameters for ultraviolet-C (UV-C, 254 nm) decontamination of filtering facepiece respirators (FFRs).
UV-C transmittance was quantified for the distinct composite layers of six N95 FFR models and used to calculate model-specific α-values, the percentage of the surface UV-C irradiance available for the internal filtering medium (IFM). Circular coupons, excised from the FFRs, were exposed to aerosolized particles containing MS2 coliphage and treated with IFM-specific UV-C doses ranging from 38 to 4707 J m(-2). Models exposed to a minimum IFM dose of 1000 J m(-2) demonstrated at least a 3 log reduction (LR) in viable MS2. Model-specific exposure times to achieve this IFM dose ranged from 2 to 266 min.
UV-C transmits into and through FFR materials. LR of MS2 was a function of model-specific IFM UV-C doses.
Filtering facepiece respirators are in high demand during infectious disease outbreaks, potentially leading to supply shortages. Reuse of disposable FFRs after decontamination has been discussed as a possible remediation strategy, but to date lacks supporting scientific evidence. The methods described here can be used to assess the likelihood that UV-C decontamination will be successful for specific FFR models.
开发一种评估过滤式面罩(FFR)经紫外线-C(UV-C,254nm)消毒后特定模型参数的方法。
对 6 种 N95 FFR 模型的不同复合层进行了 UV-C 透射率定量分析,并用于计算特定于模型的 α 值,即内部过滤介质(IFM)可用的表面 UV-C 辐照度的百分比。从 FFR 上切下的圆形小方块暴露于含有 MS2 噬菌体的气溶胶化颗粒中,并接受范围为 38 至 4707 J m(-2)的 IFM 特定 UV-C 剂量处理。暴露于至少 1000 J m(-2) IFM 剂量的模型至少使 MS2 的活菌数减少了 3 个对数级(LR)。达到该 IFM 剂量所需的特定于模型的暴露时间范围为 2 至 266 分钟。
UV-C 可以穿透 FFR 材料并进入其中。MS2 的 LR 是特定于模型的 IFM UV-C 剂量的函数。
在传染病爆发期间,过滤式面罩的需求量很大,可能导致供应短缺。人们已经讨论了对一次性 FFR 进行消毒后再使用的可能性作为一种补救策略,但迄今为止缺乏支持这一策略的科学证据。此处描述的方法可用于评估 UV-C 消毒对特定 FFR 模型成功的可能性。