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一种测定过滤式防颗粒物呼吸器消毒可用紫外线剂量的方法。

A method to determine the available UV-C dose for the decontamination of filtering facepiece respirators.

机构信息

National Institute for Occupational Safety and Health, National Personal Protective, Technology Laboratory, Pittsburgh, PA 15236, USA.

出版信息

J Appl Microbiol. 2011 Jan;110(1):287-95. doi: 10.1111/j.1365-2672.2010.04881.x. Epub 2010 Nov 4.

Abstract

AIMS

To develop a method to assess model-specific parameters for ultraviolet-C (UV-C, 254 nm) decontamination of filtering facepiece respirators (FFRs).

METHODS AND RESULTS

UV-C transmittance was quantified for the distinct composite layers of six N95 FFR models and used to calculate model-specific α-values, the percentage of the surface UV-C irradiance available for the internal filtering medium (IFM). Circular coupons, excised from the FFRs, were exposed to aerosolized particles containing MS2 coliphage and treated with IFM-specific UV-C doses ranging from 38 to 4707 J m(-2). Models exposed to a minimum IFM dose of 1000 J m(-2) demonstrated at least a 3 log reduction (LR) in viable MS2. Model-specific exposure times to achieve this IFM dose ranged from 2 to 266 min.

CONCLUSIONS

UV-C transmits into and through FFR materials. LR of MS2 was a function of model-specific IFM UV-C doses.

SIGNIFICANCE AND IMPACT OF THE STUDY

Filtering facepiece respirators are in high demand during infectious disease outbreaks, potentially leading to supply shortages. Reuse of disposable FFRs after decontamination has been discussed as a possible remediation strategy, but to date lacks supporting scientific evidence. The methods described here can be used to assess the likelihood that UV-C decontamination will be successful for specific FFR models.

摘要

目的

开发一种评估过滤式面罩(FFR)经紫外线-C(UV-C,254nm)消毒后特定模型参数的方法。

方法与结果

对 6 种 N95 FFR 模型的不同复合层进行了 UV-C 透射率定量分析,并用于计算特定于模型的 α 值,即内部过滤介质(IFM)可用的表面 UV-C 辐照度的百分比。从 FFR 上切下的圆形小方块暴露于含有 MS2 噬菌体的气溶胶化颗粒中,并接受范围为 38 至 4707 J m(-2)的 IFM 特定 UV-C 剂量处理。暴露于至少 1000 J m(-2) IFM 剂量的模型至少使 MS2 的活菌数减少了 3 个对数级(LR)。达到该 IFM 剂量所需的特定于模型的暴露时间范围为 2 至 266 分钟。

结论

UV-C 可以穿透 FFR 材料并进入其中。MS2 的 LR 是特定于模型的 IFM UV-C 剂量的函数。

研究的意义和影响

在传染病爆发期间,过滤式面罩的需求量很大,可能导致供应短缺。人们已经讨论了对一次性 FFR 进行消毒后再使用的可能性作为一种补救策略,但迄今为止缺乏支持这一策略的科学证据。此处描述的方法可用于评估 UV-C 消毒对特定 FFR 模型成功的可能性。

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