RNA 在蛋白质合成中的作用。
The roles of RNA in the synthesis of protein.
机构信息
Department of Molecular Biophysics, Yale University, New Haven, Connecticut 208114, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a003780. doi: 10.1101/cshperspect.a003780.
Abstract
The crystal structures of ribosomes that have been obtained since 2000 have transformed our understanding of protein synthesis. In addition to proving that RNA is responsible for catalyzing peptide bond formation, these structures have provided important insights into the mechanistic details of how the ribosome functions. This review emphasizes what has been learned about the mechanism of peptide bond formation, the antibiotics that inhibit ribosome function, and the fidelity of decoding.
摘要
自 2000 年以来获得的核糖体晶体结构改变了我们对蛋白质合成的理解。这些结构不仅证明了 RNA 负责催化肽键形成，还为核糖体如何发挥作用的机制细节提供了重要的见解。这篇综述强调了关于肽键形成机制、抑制核糖体功能的抗生素以及解码保真度的研究进展。
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