地理分布的差异和棘白菌素类与唑类抗真菌药物耐药率在血流感染念珠菌分离株中的表现：来自 SENTRY 抗菌药物监测计划的报告（2008 年至 2009 年）。
Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009).
机构信息
JMI Laboratories, 345 Beaver Kreek Centre, North Liberty, Iowa 52317, USA.
出版信息
J Clin Microbiol. 2011 Jan;49(1):396-9. doi: 10.1128/JCM.01398-10. Epub 2010 Nov 10.
Abstract
Antifungal testing results from the SENTRY Antimicrobial Surveillance Program (2008 to 2009) were analyzed for regional variations of invasive Candida species infections. Among 2,085 cases from the Asian-Pacific (APAC) (51 cases), Latin American (LAM) (348 cases), European (EU) (750 cases), and North American (NAM) (936 cases) regions, Candida albicans predominated (48.4%), followed by C. glabrata (18.0%), C. parapsilosis (17.2%), C. tropicalis (10.5%), and C. krusei (1.9%). Resistance to echinocandins (anidulafungin [2.4%] and micafungin [1.9%]) and azoles (3.5 to 5.6%) was most prevalent among C. glabrata isolates, as determined using recently established CLSI breakpoint criteria. C. glabrata isolates were more common in NAM (23.5%), and C. albicans isolates were more common in APAC (56.9%), with C. parapsilosis (25.6%) and C. tropicalis (17.0%) being more prominent in LAM. Emerging resistance patterns among C. glabrata cases in NAM require focused surveillance.
摘要
对 2008 年至 2009 年 SENTRY 抗菌监测计划（SENTRY Antimicrobial Surveillance Program）的抗真菌检测结果进行了分析，以了解侵袭性念珠菌属物种感染的地域差异。在亚太地区（APAC）（51 例）、拉丁美洲（LAM）（348 例）、欧洲（EU）（750 例）和北美（NAM）（936 例）的 2085 例病例中，白念珠菌（Candida albicans）占优势（48.4%），其次是近平滑念珠菌（C. glabrata）（18.0%）、近平滑念珠菌（C. parapsilosis）（17.2%）、热带念珠菌（C. tropicalis）（10.5%）和克柔念珠菌（C. krusei）（1.9%）。根据最近建立的 CLSI 折点标准，在白念珠菌中，棘白菌素（anidulafungin [2.4%] 和米卡芬净 [1.9%]）和唑类药物（3.5 至 5.6%）的耐药性最为常见。光滑念珠菌（C. glabrata）分离株在 NAM 更为常见（23.5%），而白念珠菌（C. albicans）分离株在 APAC 更为常见（56.9%），近平滑念珠菌（C. parapsilosis）（25.6%）和热带念珠菌（C. tropicalis）（17.0%）在 LAM 更为常见。在 NAM 中，C. glabrata 病例中出现的耐药模式需要重点监测。
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