白细胞介素-17 家族成员细胞因子：固有免疫中的调控和功能。
IL-17 family member cytokines: regulation and function in innate immunity.
机构信息
Department of Immunology and Center for Inflammation and Cancer, M.D. Anderson Cancer Center, Houston, TX 77054, USA.
出版信息
Cytokine Growth Factor Rev. 2010 Dec;21(6):413-23. doi: 10.1016/j.cytogfr.2010.10.002. Epub 2010 Nov 11.
Abstract
Recently, the IL-17 family member cytokines have become prominent subjects of investigation. IL-17 (IL-17A) is the best-described member of this family where its production has been mainly attributed to a specialized T helper subset of the adaptive immune response termed Th17. However, recent research on this and other Th17 cytokines has revealed new sources and functions of IL-17 family members in the innate immune response. This review will highlight recent advances in the field of IL-17 family member cytokines and will predominantly focus on the innate regulation and function of IL-17, IL-17F, and IL-25.
摘要
最近，IL-17 家族成员细胞因子已成为研究的重点。IL-17（IL-17A）是该家族中研究得最为透彻的成员，其产生主要归因于适应性免疫应答中一种称为 Th17 的特化 T 辅助细胞亚群。然而，最近对该细胞因子和其他 Th17 细胞因子的研究揭示了 IL-17 家族成员在先天免疫应答中的新来源和新功能。本综述将重点介绍 IL-17 家族成员细胞因子领域的最新进展，并主要关注 IL-17、IL-17F 和 IL-25 的先天调控和功能。
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