Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea.
Molecules. 2010 Nov 16;15(11):8251-9. doi: 10.3390/molecules15118251.
Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-ß-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.
采用胰脂肪酶抑制活性筛选方法，对禾本科莠竹属植物 Centipede grass 的甲醇提取物进行活性追踪分离，从中分离得到并鉴定了一个新的 C-糖苷黄酮类化合物，即木樨草素 6-C-β-D-槐糖苷（1），同时还分离得到了 8 个已知化合物。这些化合物的结构是基于其光谱数据的解析而确定的。在所分离得到的化合物中，C-糖苷黄酮类化合物 1-5 对胰脂肪酶表现出较强的抑制活性，其半数抑制浓度（IC₅₀）范围为 18.5 ± 2.6 至 50.5 ± 3.9 μM。
