测序抗体库：下一代技术。
Sequencing antibody repertoires: the next generation.
机构信息
NovImmune SA, Geneva, Switzerland.
出版信息
MAbs. 2011 Jan-Feb;3(1):17-20. doi: 10.4161/mabs.3.1.14169. Epub 2011 Jan 1.
Abstract
Genomic studies have been revolutionized by the use of next generation sequencing (NGS) that delivers huge amounts of sequence information in a short span of time. The number of applications for NGS is rapidly expanding and significantly transforming many areas of life sciences. The field of antibody research and discovery is no exception. Several recent studies have harnessed the power of NGS for analyzing natural or synthetic immunoglobulin repertoires with unprecedented resolution and exploring alternative paths for antibody discovery. Thus, appreciating, and then exploiting, these advances is essential for staying at the edge of antibody innovation.
摘要
基因组学研究因下一代测序（NGS）的应用而发生了革命性的变化，它在短时间内提供了大量的序列信息。NGS 的应用数量正在迅速扩大，并极大地改变了生命科学的许多领域。抗体研究和发现领域也不例外。最近的几项研究利用 NGS 的强大功能，以前所未有的分辨率分析天然或合成免疫球蛋白库，并探索抗体发现的替代途径。因此，了解并利用这些进展对于保持抗体创新的前沿至关重要。
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