Division of Weight Management & Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Pediatr Diabetes. 2011 May;12(3 Pt 2):250-7. doi: 10.1111/j.1399-5448.2010.00705.x. Epub 2010 Dec 5.
It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and metabolic syndrome (MetS) in African-American (AA) and American-White (AW) youth.
Healthy AA (n = 54) and AW (n = 54) children and adolescents (age: 8-18 yr; BMI: 15.3-42.5 kg/m(2)).
VAT mass was derived using a series of five transverse images measured by magnetic resonance imaging, extending from 5 cm below to 15 cm above L4-L5. MetS was defined using a modified IDF criteria.
In AA, VAT measure at 5 cm above L4-L5 (R(2) = 0.93) was most strongly (p < 0.05) correlated with VAT mass and was a significantly (p < 0.05) stronger correlate as compared to L4-L5 (R(2) = 0.84). In AW, VAT measures at 5 cm (R(2) = 0.93) and 10 cm (R(2) = 0.93) above L4-L5 were most strongly (p < 0.05) correlated with VAT mass; however, these were not stronger correlates as compared to L4-L5 (R(2) = 0.91). In AW, all VAT measures were significantly (p < 0.05) associated with an increased odds ratio (OR) for prevalent MetS, wherein the VAT mass [OR = 5.32(1.9-15.0)] and VAT at L4-L5[OR = 5.99(1.9-18.4)] were most strongly associated with MetS. In contrast, only VAT at 10 cm above L4-L5 [OR = 4.39 (1.1-18.1)] was significantly (p < 0.05) associated with MetS in AA.
In AA and AW youth, the measurement site for VAT has impact on the estimation of total VAT and the magnitude of the association with obesity-related health risks.
目前尚不清楚内脏脂肪组织（VAT）的测量部位是否会影响青少年时期 VAT 与相关健康风险之间的关系，如果是这样，这种关系是否存在种族差异。我们研究了 VAT 测量部位对非裔美国青少年（AA）和美国白种人（AW）青少年 VAT 与代谢综合征（MetS）之间关系的影响。
健康的 AA（n=54）和 AW（n=54）儿童和青少年（年龄：8-18 岁；BMI：15.3-42.5kg/m2）。
VAT 质量通过磁共振成像测量的五个横截面上的一系列图像得出，从 L4-L5 下方 5cm 延伸到上方 15cm。使用改良的 IDF 标准定义 MetS。
在 AA 中，L4-L5 上方 5cm（R2=0.93）处的 VAT 测量值与 VAT 质量最密切相关（p<0.05），与 L4-L5（R2=0.84）相比，相关性更强（p<0.05）。在 AW 中，L4-L5 上方 5cm（R2=0.93）和 10cm（R2=0.93）处的 VAT 测量值与 VAT 质量最密切相关；然而，与 L4-L5 相比，这些相关性并不强（R2=0.91）。在 AW 中，所有的 VAT 测量值都与更高的 MetS 患病率比值比（OR）显著相关（p<0.05），其中 VAT 质量[OR=5.32（1.9-15.0）]和 L4-L5 处的 VAT[OR=5.99（1.9-18.4）]与 MetS 的相关性最强。相比之下，只有 L4-L5 上方 10cm 处的 VAT[OR=4.39（1.1-18.1）]与 AA 中的 MetS 显著相关（p<0.05）。
在 AA 和 AW 青少年中，VAT 的测量部位会影响总 VAT 的估计以及与肥胖相关的健康风险之间的关联程度。
