Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Contact Dermatitis. 2011 May;64(5):265-72. doi: 10.1111/j.1600-0536.2010.01828.x. Epub 2010 Dec 7.
Preservatives and fragrances are important and frequent skin sensitizers, found in a wide range of products intended for personal and occupational use.
To examine the use of preservatives and fragrances in certain cosmetics and detergents on the market. The product types studied were shampoos, hair conditioners, liquid soaps, wet tissues, washing-up liquids, and multi-purpose cleaners.
MATERIALS/METHODS: Ingredient labels of 204 cosmetic products and ingredient data sheets of 97 detergents, available on company websites, were examined.
The preservatives most frequently identified were phenoxyethanol, methylparaben, sodium benzoate, propylparaben, and methylchloroisothiazolinone/methylisothiazolinone. Parabens were found in 44% of cosmetics and 9% of detergents; formaldehyde-releasers in 25% of cosmetics and 8% of detergents; and isothiazolinones in 23% of cosmetics and 28% of detergents. The fragrances most frequently identified were linalool, limonene, hexyl cinnamal, butylphenyl methylpropional, and citronellol. Eighty-eight per cent of the products contained fragrances, and any of the 26 fragrances requiring labelling were found in half of the cosmetics and one-third of the detergents.
Several preservatives and fragrances with well-known skin-sensitizing potential were common in the examined product types. Such products may be used several times a day by consumers and workers.
防腐剂和香料是重要且常见的皮肤致敏原，存在于各种个人和职业用途的产品中。
检查市场上某些化妆品和清洁剂中防腐剂和香料的使用情况。研究的产品类型包括洗发水、护发素、液体肥皂、湿纸巾、洗洁精和多用途清洁剂。
材料/方法：在公司网站上检查了 204 种化妆品的成分标签和 97 种清洁剂的成分数据表。
最常识别出的防腐剂是苯氧乙醇、甲基对羟基苯甲酸酯、苯甲酸钠、丙基对羟基苯甲酸酯和甲基氯异噻唑啉酮/甲基异噻唑啉酮。防腐剂存在于 44%的化妆品和 9%的清洁剂中；甲醛释放剂存在于 25%的化妆品和 8%的清洁剂中；异噻唑啉酮存在于 23%的化妆品和 28%的清洁剂中。最常识别出的香料是芳樟醇、柠檬烯、己基肉桂醛、丁基苯甲基丙醛和香茅醇。88%的产品含有香料，要求标签的 26 种香料中有一半在化妆品中，三分之一在清洁剂中。
几种具有已知皮肤致敏潜力的防腐剂和香料在检查的产品类型中很常见。消费者和工人可能每天会多次使用这些产品。
