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监测纺锤体方向：纺锤体位置检查点负责。

Monitoring spindle orientation: Spindle position checkpoint in charge.

机构信息

German Cancer Research Centre, DKFZ-ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

出版信息

Cell Div. 2010 Dec 11;5:28. doi: 10.1186/1747-1028-5-28.

DOI:10.1186/1747-1028-5-28
PMID:21143992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3004881/
Abstract

Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of the mitotic spindle and prevents cells from exiting mitosis when the spindle fails to align along the mother-daughter axis. SPOC is essential for maintenance of ploidy in budding yeast and similar mechanisms might exist in higher eukaryotes to ensure faithful asymmetric cell division. Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function.

摘要

在出芽酵母中，每次细胞分裂都是固有不对称的，并且依赖于有丝分裂纺锤体沿着母-子极性轴的正确定位，以实现染色体的正确分离。一种名为纺锤体位置检查点（SPOC）的监控机制，监测有丝分裂纺锤体的方向，并在纺锤体未能沿着母-子轴对齐时阻止细胞退出有丝分裂。SPOC 对于维持出芽酵母的ploidy 至关重要，类似的机制可能存在于高等真核生物中，以确保有丝分裂的准确不对称分裂。在这里，我们回顾了 SPOC 激活的当前模型，并强调了蛋白质定位和磷酸化对 SPOC 功能的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/700490874da3/1747-1028-5-28-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/94fd997ff362/1747-1028-5-28-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/223af43aef57/1747-1028-5-28-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/787ad9639bd3/1747-1028-5-28-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/3c40a6be5f14/1747-1028-5-28-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/d579e07e62aa/1747-1028-5-28-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/700490874da3/1747-1028-5-28-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/94fd997ff362/1747-1028-5-28-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/223af43aef57/1747-1028-5-28-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/787ad9639bd3/1747-1028-5-28-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/3c40a6be5f14/1747-1028-5-28-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/d579e07e62aa/1747-1028-5-28-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b87/3004881/700490874da3/1747-1028-5-28-6.jpg

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Cell. 2010 Nov 12;143(4):639-50. doi: 10.1016/j.cell.2010.09.048. Epub 2010 Oct 28.
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Stochastic Boolean model of normal and aberrant cell cycles in budding yeast.酵母细胞正常和异常细胞周期的随机布尔模型。
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LncRNAs and asymmetric cell division: The epigenetic mechanisms.长链非编码RNA与不对称细胞分裂：表观遗传机制
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