Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Cell Cycle. 2010 Dec 15;9(24):4788-94. doi: 10.4161/cc.9.24.14360.
Although we do not know everything about aging, we now know enough to start its pharmacologic suppression using clinically approved drugs. Aging turns out to be driven by sensing-signaling pathways (such as the mTOR pathway). Given that some inhibitors of the mTOR pathway are already in clinical use, there is a unique opportunity to suppress aging, while treating and preventing diseases. By itself this will answer some burning questions in gerontology. Here I discuss a proposal, starting from retrospective clinical studies to animal and cellular models to drug screens in order to develop non-toxic and effective schedules and drug combinations for extending healthy life span in our lifetime.
虽然我们对衰老的了解还不全面，但现在已经有足够的知识开始使用临床批准的药物来抑制衰老。衰老实际上是由感应信号通路（如 mTOR 通路）驱动的。鉴于 mTOR 通路的一些抑制剂已经在临床应用，因此有机会通过治疗和预防疾病来抑制衰老。这本身将回答老年医学中的一些热点问题。在这里，我从回顾性临床研究、动物和细胞模型、药物筛选等方面讨论了一个建议，以制定出在我们有生之年延长健康寿命的、无毒且有效的方案和药物组合。
