牡荆果实中的植物成分。
Phytoconstituents from Vitex agnus-castus fruits.
机构信息
UIC/NIH Center for Botanical Dietary Supplements Research, PCRPS, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Fitoterapia. 2011 Jun;82(4):528-33. doi: 10.1016/j.fitote.2010.12.003. Epub 2010 Dec 13.
Abstract
A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.
摘要
从牡荆属植物夏橘(Vitex agnus-castus L)的果实中分离得到一种新的半日花烷二萜类化合物，命名为 vitagnusin I(1)，并结合波谱数据(NMR 和 MS)对其结构进行了鉴定。同时还分离得到了 23 种已知的化合物，包括 10 种黄酮类化合物、5 种萜类化合物、3 种新木脂素类化合物、4 种酚类化合物和 1 种甘油酯。生物活性评价表明，芹菜素、3-甲基山奈酚、木樨草素和丁香脂素是δ和μ阿片受体的弱配体，具有剂量依赖性的受体结合活性。
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