囊性纤维化中铜绿假单胞菌的表型转化
Phenotypic conversion of Pseudomonas aeruginosa in cystic fibrosis.
作者信息
Fegan M, Francis P, Hayward A C, Davis G H, Fuerst J A
机构信息
Department of Microbiology, University of Queensland, St. Lucia, Australia.
出版信息
J Clin Microbiol. 1990 Jun;28(6):1143-6. doi: 10.1128/jcm.28.6.1143-1146.1990.
Abstract
Pseudomonas aeruginosa strains isolated from cystic fibrosis patients were tested for production of exoenzymes, sensitivity to pooled normal human serum, and colony morphology. Strains isolated from patients exhibiting a severe form of the disease were seen to produce a decreased range of exoenzymes, to show an increase in their serum sensitivity, and to be predominantly mucoid in colonial character compared with strains isolated from patients with a milder form of the disease. These results suggest that P. aeruginosa undergoes phenotypic changes with respect to exoenzyme secretion, serum sensitivity, and colony form as the clinical condition of the cystic fibrosis patient changes.
摘要
对从囊性纤维化患者中分离出的铜绿假单胞菌菌株进行了外酶产生、对正常人混合血清的敏感性以及菌落形态的检测。与从病情较轻的患者中分离出的菌株相比，从表现出严重疾病形式的患者中分离出的菌株产生的外酶种类减少，血清敏感性增加，并且菌落特征主要为黏液样。这些结果表明，随着囊性纤维化患者临床状况的变化，铜绿假单胞菌在外酶分泌、血清敏感性和菌落形态方面会发生表型变化。
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