National Institute of Chemistry, Ljubljana, Slovenia.
Acta Pharm. 2010 Dec;60(4):373-85. doi: 10.2478/v1007-010-0037-4.
Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.
在过去的几年中，有序介孔硅作为药物传递装置的兴趣和发展已经大大增加。在文献中精选的案例中，已经证明了这些系统作为传递装置的有效性。具体来说，展示了如何通过将它们嵌入介孔硅中来增强难溶性药物的释放动力学。此外，还简要回顾了控制模型药物酮康唑在 SBA-15 基质中释放的结构和释放的关键因素。在更苛刻的条件下对介孔基质表面进行功能化的可能性也为设计刺激响应药物释放提供了广泛的平台，包括 pH 响应系统和对特定离子、还原剂、磁场或紫外光存在做出响应的系统，其在体外已经得到了验证。
