Sheffield NIHR Bone Biomedical Research Unit, University of Sheffield and Sheffield Teaching Hospital Foundation Trust, Centre for Biomedical Research, Herries Road, Sheffield S5 7AU, South Yorkshire, UK.
Osteoporos Int. 2011 Oct;22(10):2721-31. doi: 10.1007/s00198-010-1513-x. Epub 2010 Dec 18.
Premenopausal women with low calcium intakes consumed calcium-fortified ice cream daily for 28 days. Bone markers, NTX, CTX and PTH decreased significantly by 7 days, with some evidence of a calcium dose-dependent effect. Bone marker responses were observed within 1 h of consuming ice cream. Body weight remained constant over 28 days.
Dietary calcium is important for lifelong bone health. Milk is a good source of bioavailable calcium, but consumption has declined among young adults. The aims were to determine whether calcium-fortified ice cream, a palatable source of calcium, produces significant, sustainable changes in bone turnover markers and parathyroid hormone (PTH) in premenopausal women with calcium intake below recommended UK levels.
Eighty women, ages 20-39 years (calcium intake <750 mg/day) were randomised to consume lower saturated fat/sugar ice cream containing 96, 244, 459 or 676 mg calcium daily for 28 days. Urinary NTX/Cr, serum CTX, PINP, 1,25D and PTH were measured (baseline, days 1, 7 and 28). Acute changes in CTX and PTH were measured over 5 h (n = 29 women).
There were significant mean decreases by 7 days in NTX/Cr, CTX, PTH and 1,25D and increases in PINP (one sample t tests), with a significant dose-dependent effect on CTX analysis of covariance. Only CTX remained suppressed at 28 days. Serum CTX and PTH decreased within 1 h. Body weight did not change significantly between baseline and 28 days.
Daily consumption of calcium-fortified ice cream by premenopausal women may significantly reduce levels of the bone resorption marker serum CTX, without stimulating weight gain. The ice cream could be incorporated into the diet to replace low-calcium snacks and thus help individuals with habitually low calcium intakes to meet recommended intakes. The 244 mg calcium preparation would provide more than a quarter of the UK daily recommended nutrient intake for premenopausal women.
膳食钙对于终生骨骼健康很重要。牛奶是钙的良好生物利用源，但在年轻人中的摄入量有所下降。本研究旨在评估一种美味的富钙食物——钙强化冰淇淋，是否能使钙摄入量低于英国推荐水平的绝经前妇女的骨转换标志物和甲状旁腺激素（PTH）产生显著且可持续的变化。
80 名 20-39 岁（钙摄入量＜750mg/d）的女性被随机分配，每天食用低饱和脂肪/低糖冰淇淋，分别含有 96、244、459 或 676mg 钙，持续 28 天。在基线、第 1、7 和 28 天，检测尿 NTX/Cr、血清 CTX、PINP、1,25D 和 PTH。（n=29 名女性）在 5 小时内检测了 CTX 和 PTH 的急性变化。
与基线相比，7 天时 NTX/Cr、CTX、PTH 和 1,25D 显著降低，PINP 显著升高（单样本 t 检验），经协方差分析发现 CTX 存在剂量依赖性。28 天时仅 CTX 仍受到抑制。血清 CTX 和 PTH 在 1 小时内下降。基线和 28 天时体重无显著变化。
绝经前女性每天食用钙强化冰淇淋可能会显著降低血清 CTX 这一骨吸收标志物的水平，而不会刺激体重增加。这种冰淇淋可以纳入饮食中，以替代低钙零食，从而帮助习惯性低钙摄入的个体达到推荐的摄入量。244mg 钙制剂可提供英国绝经前女性每日推荐营养素摄入量的四分之一以上。
