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肺部的免疫反应:基本原则

Immune responses in the lung: basic principles.

作者信息

Agostini C, Semenzato G

机构信息

Istituto di Medicina Clinica dell' Universitá degli Studi di Padova, Italy.

出版信息

Lung. 1990;168 Suppl:1001-12. doi: 10.1007/BF02718238.

DOI:10.1007/BF02718238
PMID:2117101
Abstract

The basic elements which regulate immunomodulation at the lung level and the constituents of in situ pulmonary host defense mechanisms that recognize, destroy, and remove potentially harmful inhaled antigenic materials are discussed. The relevance of these processes in term of pathogenesis of some lung disorders is briefly exemplified.

摘要

本文讨论了在肺部水平调节免疫调节的基本要素,以及原位肺部宿主防御机制的组成部分,这些机制能够识别、破坏和清除潜在有害的吸入性抗原物质。并简要举例说明了这些过程在某些肺部疾病发病机制中的相关性。

相似文献

1
Immune responses in the lung: basic principles.肺部的免疫反应:基本原则
Lung. 1990;168 Suppl:1001-12. doi: 10.1007/BF02718238.
2
Role of alveolar macrophage- and lung T cell-derived mediators in pulmonary sarcoidosis.肺泡巨噬细胞和肺T细胞衍生介质在结节病中的作用。
Ann N Y Acad Sci. 1986;465:82-90. doi: 10.1111/j.1749-6632.1986.tb18483.x.
3
Antigen presentation by alveolar macrophages in patients with sarcoidosis.结节病患者肺泡巨噬细胞的抗原呈递
Ann N Y Acad Sci. 1986;465:74-81. doi: 10.1111/j.1749-6632.1986.tb18482.x.
4
Immunology and the lung: an overview.
Semin Roentgenol. 1975 Jan;10(1):7-19. doi: 10.1016/0037-198x(75)90005-x.
5
Role of T- and B-lymphocytes in pulmonary host defences.T淋巴细胞和B淋巴细胞在肺部宿主防御中的作用。
Eur Respir J. 2001 Nov;18(5):846-56. doi: 10.1183/09031936.01.00229001.
6
Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages.下呼吸道免疫反应的下调:肺泡巨噬细胞的作用
Clin Exp Immunol. 1986 Feb;63(2):261-70.
7
[Immunity of the "deep lung"].
G Clin Med. 1990 Apr;71(4):275-82.
8
Pulmonary immune cells in health and disease: lymphocytes.健康与疾病状态下的肺部免疫细胞:淋巴细胞
Eur Respir J. 1993 Oct;6(9):1378-401.
9
[Immunobiology of the lower respiratory tree].
Rev Med Chil. 1984 Sep;112(9):951-7.
10
In defense of the lung: paradoxical role of the pulmonary alveolar macrophage.为肺辩护:肺泡巨噬细胞的矛盾作用。
Ann Allergy. 1985 Nov;55(5):634-50.

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Phenotypic markers of alveolar macrophage maturation in pulmonary sarcoidosis.肺结节病中肺泡巨噬细胞成熟的表型标志物。
Lung. 1993;171(5):293-303. doi: 10.1007/BF03215872.

本文引用的文献

1
Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. Site of increased antibody production and role of T lymphocytes.肺结节病中高丙种球蛋白血症的机制。抗体产生增加的部位及T淋巴细胞的作用。
J Clin Invest. 1981 Jan;67(1):86-92. doi: 10.1172/JCI110036.
2
Bronchoalveolar lavage and lung histology. Comparative analysis of inflammatory and immunocompetent cells in patients with sarcoidosis and hypersensitivity pneumonitis.支气管肺泡灌洗与肺组织学。结节病和过敏性肺炎患者炎症及免疫活性细胞的比较分析。
Am Rev Respir Dis. 1985 Aug;132(2):400-4. doi: 10.1164/arrd.1985.132.2.400.
3
Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis.
获得性免疫缺陷综合征患者的支气管肺泡灌洗细胞和蛋白质。一项免疫学分析。
Ann Intern Med. 1985 Oct;103(4):522-33. doi: 10.7326/0003-4819-103-4-522.
4
Tumor necrosis factor production by human sarcoid alveolar macrophages.人结节病肺泡巨噬细胞产生肿瘤坏死因子
Am J Pathol. 1986 Dec;125(3):421-5.
5
AIDS virus-specific cytotoxic T lymphocytes in lung disorders.肺部疾病中的艾滋病病毒特异性细胞毒性T淋巴细胞
Nature. 1987;328(6128):348-51. doi: 10.1038/328348a0.
6
Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset.在活动性肺结节病中,肺T淋巴细胞自发释放白细胞介素2主要来自Leu3+DR+ T细胞亚群。
J Clin Invest. 1986 Jun;77(6):1962-70. doi: 10.1172/JCI112525.
7
Does de novo immunoglobulin synthesis occur on the epithelial surface of the human lower respiratory tract?
Am Rev Respir Dis. 1988 Jan;137(1):17-24. doi: 10.1164/ajrccm/137.1.17.
8
Different types of cytotoxic lymphocytes recovered from the lungs of patients with hypersensitivity pneumonitis.
Am Rev Respir Dis. 1988 Jan;137(1):70-4. doi: 10.1164/ajrccm/137.1.70.
9
Phenotypical and functional analysis of bronchoalveolar lavage lymphocytes in patients with HIV infection.
Am Rev Respir Dis. 1988 Dec;138(6):1609-15. doi: 10.1164/ajrccm/138.6.1609.
10
Evidence for a cytotoxic T-lymphocyte alveolitis in human immunodeficiency virus-infected patients.人类免疫缺陷病毒感染患者中细胞毒性T淋巴细胞肺泡炎的证据。
AIDS. 1988 Jun;2(3):179-83.