Bujia J, Wilmes E, Krombach F, Hammer C, Kastenbauer E
Department of Otorhinolaryngology, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
Eur Arch Otorhinolaryngol. 1990;247(5):287-90. doi: 10.1007/BF00176539.
HLA class II antigens play an important role in the immunological response. In this study, we report on HLA class II antigen expression in vitro by human nasal cartilage cells as detected with an immunoperoxidase staining and immunofluorescence flow cytometric analysis using monoclonal antibodies. Their expression was induced during a 7-day incubation period with gamma-interferon. These findings suggest that a possible mode of action of the preservation methods of cartilage allografts for inducing a prolonged acceptance time is based on the prevention of HLA class II antigen expression by the cartilage cells.
人类白细胞抗原II类抗原在免疫反应中起重要作用。在本研究中，我们报告了用人鼻软骨细胞体外表达人类白细胞抗原II类抗原的情况，通过免疫过氧化物酶染色和使用单克隆抗体的免疫荧光流式细胞术分析进行检测。在与γ干扰素孵育7天的过程中诱导了它们的表达。这些发现表明，同种异体软骨移植物保存方法延长接受时间的一种可能作用方式是基于防止软骨细胞表达人类白细胞抗原II类抗原。
