CSM Innovation, Diemen, The Netherlands.
Nutr Rev. 2011 Jan;69(1):22-33. doi: 10.1111/j.1753-4887.2010.00357.x.
Epidemiological and animal data show associations between whole grain and dietary fiber intakes and disease risk reduction. Dietary fiber can be considered a "black box" since its molecular structure can vary significantly. Limited data are available linking the health effects of dietary fiber to certain molecular structures. The present review was conducted to examine the existing knowledge of structure/effect relationships with a focus on human intervention studies that examined the relationships between the molecular structure of cereal dietary fiber and both the blood glucose and insulin responses and gut health. An extensive search of the existing literature was conducted using the PubMed database for the period 1993-2008. Of 48 publications originally identified using the search criteria, 13 provided molecular information in conjunction with fiber type. Several indications show a link between molecular structure and physiological effects. Limited data from human intervention trials are available to verify hypotheses derived from in vitro studies that relate the molecular structure of cereal dietary fiber to both insulin and glucose response and gut health.
流行病学和动物数据表明，全谷物和膳食纤维的摄入与疾病风险的降低有关。膳食纤维可以被视为一个“黑匣子”，因为它的分子结构可能有很大的差异。目前可用的将膳食纤维的健康效应与某些分子结构联系起来的数据有限。本综述旨在检查现有的关于结构/效应关系的知识，重点是研究谷物膳食纤维的分子结构与血糖和胰岛素反应以及肠道健康之间关系的人体干预研究。使用 PubMed 数据库对 1993 年至 2008 年期间的现有文献进行了广泛的搜索。最初使用搜索标准确定了 48 篇出版物，其中 13 篇提供了纤维类型的分子信息。有几个迹象表明分子结构和生理效应之间存在联系。目前只有有限的人体干预试验数据可以验证来自体外研究的假设，这些假设涉及谷物膳食纤维的分子结构与胰岛素和葡萄糖反应以及肠道健康的关系。
