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6,7,9,10-四氢-16,22-亚乙基-氧代乙撑-5,8,11,19-四氧杂-16,22-二氮杂二苯并[h,q]环十八碳二烯-17,21-二酮：一种苄基稠合的大环二酰胺。

6,7,9,10-Tetra-hydro-16,22-ethano-oxyethano-5,8,11,19-tetra-oxa-16,22-diaza-dibenzo[h,q]cyclo-octa-decine-17,21-dione: a benzyl-annelated macrobicyclic diamide.

作者信息

Smith Gary L N, Lei Yang, Powell Douglas R, Taylor Richard W

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 24;64(Pt 10):o2003. doi: 10.1107/S1600536808030067.

DOI:10.1107/S1600536808030067
PMID:21201201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2959315/
Abstract

The macrobicyclic title compound, C(24)H(28)N(2)O(7), has two tertiary diamide bridgehead atoms and is composed of a 12-membered ring (N(2)O(2) donor set) and two 18-membered rings (N(2)O(4) donor sets). The solid-state structure shows that each of the amide groups is not coplanar with the adjacent benzene ring and NMR studies indicate that this conformational relationship persists in solution.

摘要

大环标题化合物C(24)H(28)N(2)O(7)有两个叔二酰胺桥头原子，由一个12元环（N(2)O(2)供体组）和两个18元环（N(2)O(4)供体组）组成。固态结构表明，每个酰胺基团与相邻苯环不共面，核磁共振研究表明这种构象关系在溶液中持续存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0c/2959315/746726060a5b/e-64-o2003-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0c/2959315/746726060a5b/e-64-o2003-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0c/2959315/746726060a5b/e-64-o2003-fig1.jpg

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