Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Cardiol Res Pract. 2010 Dec 22;2011:286509. doi: 10.4061/2011/286509.
Objective. Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism. The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP). Methods. Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residing in central Massachusetts. Data were collected at baseline and at quarterly intervals over a one-year period per individual. Multivariable linear mixed models were used to assess the association for the entire sample and by gender. Results. The mean Beck Depression Inventory score was 5.8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.2). Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP. Analyses by gender show persistence of an independent association among women, but not among men. Body mass index (BMI = weight(kg)/height(m)(2)) appears to be a partial mediator of this relationship. Conclusion. Depression score was correlated to hs-CRP levels in women. Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.
抑郁与心血管疾病风险增加有关，而抑郁相关的高敏 C 反应蛋白（hs-CRP）升高被认为是一种可能的机制。本文旨在探讨抑郁与高敏 C 反应蛋白（hs-CRP）之间的关系。
研究对象为马萨诸塞州中部 508 名健康成年人（平均年龄 48.5 岁；49%为女性，88%为白人）。数据由每位个体在基线和每年四个季度的间隔时间内收集。采用多变量线性混合模型评估整个样本和性别分层的相关性。
贝克抑郁量表的平均得分为 5.8（标准差 5.4；中位数 4.3），平均血清 hs-CRP 为 1.8mg/L（标准差 1.7；中位数 1.2）。多变量线性混合模型的结果表明，抑郁得分较高的个体 hs-CRP 水平较高。性别分层分析显示，女性存在独立的相关性，而男性则没有。体重指数（BMI=体重（kg）/身高（m）^2）似乎是这种关系的部分中介因素。
抑郁评分与女性的 hs-CRP 水平相关。需要进一步的研究来阐明这些关联的生物学机制及其意义。
