Lehrstuhl für Organische Chemie I, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
Angew Chem Int Ed Engl. 2011 Feb 1;50(5):1000-45. doi: 10.1002/anie.201002845. Epub 2011 Jan 18.
Photochemical reactions contribute in a significant way to the existing repertoire of carbon-carbon bond-forming reactions by allowing access to exceptional molecular structures that cannot be obtained by conventional means. In this Review, the most important photochemical transformations that have been employed in natural product synthesis are presented. Selected total syntheses are discussed as examples, with particular attention given to the photochemical key step and its stereoselectivity. The structural relationship between the photochemically generated molecule and the natural product is shown, and, where necessary, the consecutive reactions in the synthesis are illustrated and classified.
光化学反应通过提供传统方法无法获得的特殊分子结构，为现有的碳-碳键形成反应库做出了重要贡献。在这篇综述中，介绍了在天然产物合成中应用的最重要的光化学转化。选择了一些代表性的全合成作为例子进行讨论，特别关注光化学关键步骤及其立体选择性。展示了光化学生成的分子与天然产物之间的结构关系，并在必要时说明了合成中的后续反应并进行了分类。
