快速音圈扫描光学分辨率光声显微镜。
Fast voice-coil scanning optical-resolution photoacoustic microscopy.
机构信息
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
出版信息
Opt Lett. 2011 Jan 15;36(2):139-41. doi: 10.1364/OL.36.000139.
Abstract
We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micrometer-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, demonstrating the capability to image highly dynamic processes in vivo at a micrometer-scale resolution.
摘要
我们开发了一种具有实时成像能力和光学分辨率的光声成像系统。该成像系统能够以 20 Hz 的速度在 9mm 范围内进行扫描，以 40 Hz 的速度在 1mm 扫描范围内进行扫描。聚焦激光束在非散射介质中的横向分辨率为 3.4μm。在硅管中流动的微米级碳颗粒或全血以及小鼠耳毛细血管中的单个红细胞（RBC）也被实时成像，这证明了以微米级分辨率在体内实时成像高度动态过程的能力。
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