Universidade Federal de São Carlos, Laboratório de Produtos Naturais, Departamento de Química, São Carlos, SP, Brazil.
Anticancer Agents Med Chem. 2010 Dec;10(10):769-76. doi: 10.2174/187152010794728620.
Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.
六种三萜和八种柠檬苦素被评估其抑制三种人类肿瘤细胞系（乳腺癌 MCF-7、非小细胞肺癌 NCI-H460 和黑色素瘤 A375-C5）生长的能力。通过研究它们对细胞周期谱和程序性细胞死亡的影响，研究了观察到的细胞生长抑制的四个最有效化合物的作用机制。结果表明，一种三萜（odoratol）和两种柠檬苦素（gedunin 和 cedrelone）导致细胞周期停滞，而只有柠檬苦素 gedunin 和 cedrelone 被发现是非常有效的凋亡诱导剂。
