Departamento de Gerontologia, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, CEP 13565-905, São Carlos, SP, Brazil.
Anticancer Agents Med Chem. 2013 Dec;13(10):1645-53. doi: 10.2174/18715206113139990314.
Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compounds which could be the basis for the design of new anti-tumor drugs, with fewer side effects than the conventional chemotherapy used currently. Cedrelone is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of cedrelone to inhibit MMP activity. We also demonstrate that cedrelone is able to induce apoptosis in MDA-MB-231 cells. There are only a few works investigating the effect of limonoids in cellular processes closely related to tumor progression such as adhesion, migration and invasion. To the best of our knowledge, this is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.
癌症是仅次于心血管疾病的第二大死亡原因，有流行病学证据表明，这种趋势正在全球范围内出现。巴西拥有广泛的植物生物多样性，其中有超过 55000 种被记录在案。这种生物多样性有助于发现可能成为设计新型抗肿瘤药物基础的化合物，这些药物的副作用比目前使用的传统化疗要少。 Cedrelone 是从 Trichilia catigua（芸香科）中分离出来的一种 limonoid，是一种原产于巴西的植物。这项研究表明， Cedrelone 可抑制 MDA-MB-231 细胞系中乳腺癌细胞的增殖、黏附、迁移和侵袭。 Cedrelone 抑制 MMP 活性，至少部分解释了 MDA-MB-231 细胞迁移和侵袭的作用。我们还证明 Cedrelone 能够诱导 MDA-MB-231 细胞凋亡。只有少数研究调查了 limonoids 对与肿瘤进展密切相关的细胞过程（如黏附、迁移和侵袭）的影响。据我们所知，这是第一项描述 limonoid 对肿瘤和非肿瘤细胞黏附过程影响的研究。
