Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA.
J Magn Reson Imaging. 2011 Feb;33(2):306-11. doi: 10.1002/jmri.22460.
To establish normative metabolite ratios throughout the newborn brain using three-dimensional (3D) MR spectroscopic imaging (MRSI).
MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. Fifty-five newborn subjects (28.4 ± 2.6 weeks postconception age at birth, 34.1 ± 3.1 weeks postconception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (neuromotor score = 0, mental development index score > 85) at age 12 months.
The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions.
Brain metabolites can be obtained through in vivo 3D MRSI and used to monitor newborn brain maturation.
利用三维（3D）磁共振波谱成像（MRSI）在新生儿大脑中建立规范的代谢物比值。
MRI 和 MRSI 一直是评估新生儿正常和异常神经元成熟的有用工具。在这项研究中，我们除了进行全面的解剖和其他功能成像方法来检查成熟度外，还进行了全脑 3D MRSI。55 名新生儿受试者（出生时妊娠年龄为 28.4 ± 2.6 周，扫描时妊娠年龄为 34.1 ± 3.1 周，男性 32 名，女性 23 名）具有高质量的 MRSI 研究（104 次检查），并且在 12 个月时具有正常的神经发育结局（运动神经评分=0，精神发育指数评分＞85）。
所有区域的 NAA 与 Cho 比值均随年龄增长而显著增加。丘脑、基底神经节、皮质脊髓束和顶叶白质等区域的 Lac 与 NAA 比值随年龄显著下降，其他区域呈下降趋势。
可以通过体内 3D MRSI 获得脑代谢物，并用于监测新生儿脑成熟度。
