Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan 48207, USA.
Biol Psychiatry. 2011 May 1;69(9):883-9. doi: 10.1016/j.biopsych.2010.12.011. Epub 2011 Jan 28.
Repetition suppression (RS) phenomena, such as those observed using paired-identical-stimulus (S1-S2) paradigms, likely reflect adaptive functions such as habituation and, more specifically, sensory gating.
To better characterize the neural networks underlying RS, we analyzed auditory S1-S2 data from electrodes placed on the cortices of 64 epilepsy patients who were being evaluated for surgical therapy. We identified regions with maximal amplitude responses to S1 (i.e., stimulus registration regions), regions with maximal suppression of responses to S2 relative to S1 (i.e., RS), and regions with no or minimal RS.
Auditory perceptual regions, such as the superior temporal gyri, were shown to have significant initial registration activity (i.e., strong response to S1). Several prefrontal, cingulate, and parietal lobe regions were found to exhibit stronger RS than those recorded from the auditory perceptual areas.
The data strongly suggest that the neural network underlying repetition suppression may include regions not previously thought to be involved, such as the parietal and cingulate cortexes. In addition, the data also support the notion that the initial response to stimuli and the ability to suppress the stimuli if repeated are two separate, but likely related, functions.
重复抑制（RS）现象，如使用成对相同刺激（S1-S2）范式观察到的现象，可能反映了适应功能，如习惯化，更具体地说，是感觉门控。
为了更好地描述 RS 所涉及的神经网络，我们分析了 64 名正在接受手术治疗评估的癫痫患者皮层上放置的电极的听觉 S1-S2 数据。我们确定了对 S1 有最大幅度反应的区域（即刺激登记区域）、对 S2 的反应相对于 S1 有最大抑制的区域（即 RS）以及没有或最小 RS 的区域。
听觉感知区域，如颞上回，显示出显著的初始登记活动（即对 S1 的强烈反应）。与从听觉感知区域记录到的相比，发现几个前额叶、扣带回和顶叶区域表现出更强的 RS。
数据强烈表明，重复抑制的神经网络可能包括以前认为不参与的区域，如顶叶和扣带回皮层。此外，数据还支持这样一种观点，即对刺激的初始反应和重复刺激时抑制刺激的能力是两个独立但可能相关的功能。
