运动与食物联合防治神经认知障碍。
The combined effects of exercise and foods in preventing neurological and cognitive disorders.
机构信息
Dept. of Integrative Biology and Physiology, and Dept. of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Prev Med. 2011 Jun;52 Suppl 1(Suppl 1):S75-80. doi: 10.1016/j.ypmed.2011.01.023. Epub 2011 Jan 31.
OBJECTIVE
Exercise and select diets have important influences on health and plasticity of the nervous system, and the molecular mechanisms involved with these actions are starting to be elucidated. New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity.
METHODS
Published studies in animals and humans describing the effects of exercise and diets in brain plasticity and cognitive abilities are discussed.
RESULTS
New evidence indicates that exercise and select diets exert their effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity. An important instigator in the molecular machinery stimulated by exercise is brain-derived neurotrophic factor (BDNF), which acts at the interface of metabolism and plasticity.
CONCLUSIONS
Recent studies show that selected dietary factors share similar mechanisms with exercise, and in some cases they can complement the action of exercise. Therefore, exercise and dietary management appear as a non-invasive and effective strategy to counteract neurological and cognitive disorders.
目的
运动和选择饮食对神经系统的健康和可塑性有重要影响，涉及这些作用的分子机制开始被阐明。新的证据表明，运动与饮食因素相结合，通过影响与能量代谢和突触可塑性管理相关的分子事件来发挥其作用。
方法
讨论了描述运动和饮食对大脑可塑性和认知能力影响的已发表的动物和人类研究。
结果
新的证据表明，运动和选择的饮食通过影响与能量代谢和突触可塑性管理相关的分子事件来发挥其作用。运动刺激的分子机制中的一个重要启动子是脑源性神经营养因子（BDNF），它作用于代谢和可塑性的界面。
结论
最近的研究表明，某些饮食因素与运动具有相似的机制，在某些情况下，它们可以补充运动的作用。因此，运动和饮食管理似乎是一种非侵入性和有效的策略，可以对抗神经和认知障碍。
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