成功使用泊沙康唑治疗由婴儿利什曼原虫引起的旧世界皮肤利什曼病。
Successful treatment of Old World cutaneous leishmaniasis caused by Leishmania infantum with posaconazole.
机构信息
Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center (University Hospital of Columbia University College of Physicians and Surgeons), St. Luke's Division, Clark 4th floor, 1111 Amsterdam Avenue, New York, NY 10025, USA.
出版信息
Antimicrob Agents Chemother. 2011 Apr;55(4):1774-6. doi: 10.1128/AAC.01498-10. Epub 2011 Jan 31.
Abstract
Old World cutaneous leishmaniasis is a widespread and potentially disfiguring protozoal infection that is endemic in the Mediterranean basin, Africa, and parts of Asia. Human infection is caused by several species of Leishmania parasites, such as Leishmania infantum. Available systemic and topical treatments vary in efficacy and are often unjustified due to their toxicity. We report on a case that was treated with posaconazole, a drug typically considered an antifungal agent but which also targets specific metabolic pathways of the parasite.
摘要
旧大陆皮肤利什曼病是一种广泛存在且可能导致毁容的原生动物感染，在地中海盆地、非洲和亚洲部分地区流行。人类感染是由几种利什曼原虫寄生虫引起的，如利什曼原虫婴儿。现有的全身和局部治疗方法在疗效上存在差异，而且由于其毒性，往往是不合理的。我们报告了一例使用泊沙康唑治疗的病例，泊沙康唑通常被认为是一种抗真菌药物，但也针对寄生虫的特定代谢途径。
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