Content-based histopathology image retrieval using a kernel-based semantic annotation framework.

Large amounts of histology images are captured and archived in pathology departments due to the ever expanding use of digital microscopy. The ability to manage and access these collections of digital images is regarded as a key component of next generation medical imaging systems. This paper addresses the problem of retrieving histopathology images from a large collection using an example image as query. The proposed approach automatically annotates the images in the collection, as well as the query images, with high-level semantic concepts. This semantic representation delivers an improved retrieval performance providing more meaningful results. We model the problem of automatic image annotation using kernel methods, resulting in a unified framework that includes: (1) multiple features for image representation, (2) a feature integration and selection mechanism (3) and an automatic semantic image annotation strategy. An extensive experimental evaluation demonstrated the effectiveness of the proposed framework to build meaningful image representations for learning and useful semantic annotations for image retrieval.