Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Str. 1, 35032 Marburg, Germany.
Nat Rev Cancer. 2011 Mar;11(3):177-87. doi: 10.1038/nrc3003. Epub 2011 Feb 10.
The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease.
癌细胞侵入周围组织是转移的前提和初始步骤，转移是癌症死亡的主要原因。侵袭性细胞迁移需要形成各种结构，如入侵伪足和伪足，这需要受专门的肌动蛋白成核因子调节的肌动蛋白组装。在人类细胞中有大量不同的肌动蛋白成核因子，如形成蛋白、螺旋蛋白和 Arp2/3 调节蛋白，而且这个列表可能还会增加。研究参与癌细胞功能的各种肌动蛋白成核因子的机制最终可能为侵袭性和转移性疾病提供新的治疗方法。
