Department of Ophthalmology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel.
Graefes Arch Clin Exp Ophthalmol. 2011 Feb;249(2):179-82. doi: 10.1007/s00417-010-1489-4. Epub 2010 Aug 18.
To examine the association between age-related macular degeneration (AMD) and the risk of myocardial infarctions (MIs) in a large health maintenance organization.
A retrospective cohort study carried out at Maccabi Healthcare Services (MHS).
A total of 6,546 patients aged ≥65 years who were diagnosed with AMD between April 18 1996 and June 6 2008, and 61,672 non-AMD patients frequency-matched for age and gender.
Participants were retrospectively followed to the day of leaving the MHS, to undergoing an MI, or to closure of the study on July 1 2008, whichever came earlier. The relative risk of MI associated with AMD was estimated using the Cox proportional hazard model.
Incident myocardial infarction events.
During the study period, there were 159 (5.1 per 1,000 person years [PY]) and 2,997 (4.2 per 1,000 PY) MIs respectively in the AMD and non-AMD patient groups. The age- and gender-adjusted hazard ratio (HR) of MI among AMD patients was 1.01 (95%CI: 0.85-1.20). Baseline medical characteristics associated with increased risk of mortality included diabetes mellitus, hypertension, older age, and male gender. The fully adjusted HR associated with AMD was 1.03 (95%CI: 0.87-1.22).
Despite the shared risk factors associated with AMD and MIs, we found no increased risk of MI in AMD patients.
在大型医疗保健组织中研究年龄相关性黄斑变性（AMD）与心肌梗死（MI）风险之间的关联。
在 Maccabi 医疗保健服务（MHS）进行的回顾性队列研究。
共有 6546 名年龄≥65 岁的患者，他们在 1996 年 4 月 18 日至 2008 年 6 月 6 日之间被诊断为 AMD，并且有 61672 名非 AMD 患者按照年龄和性别进行了频率匹配。
回顾性随访参与者，直至离开 MHS、发生 MI 或 2008 年 7 月 1 日研究结束，以先到者为准。使用 Cox 比例风险模型估计与 AMD 相关的 MI 的相对风险。
心肌梗死事件的发生率。
在研究期间，AMD 和非 AMD 患者组分别发生了 159 例（5.1/1000 人年）和 2997 例（4.2/1000 人年）MI。AMD 患者的年龄和性别调整后的 MI 风险比（HR）为 1.01（95%CI：0.85-1.20）。与死亡率增加相关的基线医学特征包括糖尿病、高血压、年龄较大和男性。与 AMD 相关的完全调整后的 HR 为 1.03（95%CI：0.87-1.22）。
尽管 AMD 和 MI 存在共同的危险因素，但我们未发现 AMD 患者的 MI 风险增加。
