Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, Leuven, Belgium.
Aliment Pharmacol Ther. 2011 Apr;33(8):880-94. doi: 10.1111/j.1365-2036.2011.04609.x. Epub 2011 Feb 22.
From a classical point of view, gastric motility acts to clear the stomach between meals, whereas postprandial motility acts to provide a reservoir for food, mixing and grinding the food and to assure a controlled flow of food to the intestines.
To summarise findings that support the role of gastric motility as a central mediator of hunger, satiation and satiety.
A literature review using the search terms 'satiety', 'satiation' and 'food intake' was combined with specific terms corresponding to the sequence of events during and after food intake.
During food intake, when gastric emptying of especially solids is limited, gastric distension and gastric accommodation play an important function in the regulation of satiation. After food intake, when the stomach gradually empties, the role of gastric distension in the determination of appetite decreases and the focus will shift to gastric emptying and intestinal exposure of the nutrients. Finally, we have discussed the role of the empty stomach and the migrating motor complex in the regulation of hunger signals.
Our findings indicate that gastric motility is a key mediator of hunger, satiation and satiety. More specifically, gastric accommodation and gastric emptying play important roles in the regulation of gastric (dis)tension and intestinal exposure of nutrients and hence control satiation and satiety. Correlations between gastric accommodation, gastric emptying and body weight indicate that gastric motility can also play a role in the long-term regulation of body weight.
从经典观点来看，胃运动的作用是在两餐之间清空胃，而餐后运动的作用是为食物提供储存库，混合和研磨食物，并确保食物向肠道的受控流动。
总结支持胃运动作为饥饿、饱腹感和饱足感的中枢介质的研究结果。
使用搜索词“饱腹感”、“饱腹感”和“食物摄入”进行文献综述，并结合与进食和进食后事件序列相对应的特定术语。
在进食过程中，当固体特别是固体的胃排空受到限制时，胃膨胀和胃顺应性在调节饱腹感方面发挥着重要作用。进食后，当胃逐渐排空时，胃膨胀在确定食欲中的作用会降低，注意力将转移到胃排空和肠道暴露营养素上。最后，我们讨论了空腹和移行性运动复合体在饥饿信号调节中的作用。
我们的研究结果表明，胃运动是饥饿、饱腹感和饱足感的关键介质。更具体地说，胃顺应性和胃排空在调节胃（膨胀）和肠道暴露营养素方面发挥着重要作用，从而控制饱腹感和饱足感。胃顺应性、胃排空和体重之间的相关性表明，胃运动也可以在体重的长期调节中发挥作用。
