再巩固过程中的蛋白质降解作为记忆重组的一种机制
Protein Degradation during Reconsolidation as a Mechanism for Memory Reorganization.
作者信息
Kaang Bong-Kiun, Choi Jun-Hyeok
机构信息
National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University Seoul, South Korea.
出版信息
Front Behav Neurosci. 2011 Feb 1;5:2. doi: 10.3389/fnbeh.2011.00002. eCollection 2011.
Abstract
Memory is a reference formed from a past experience that is used to respond to present situations. However, the world is dynamic and situations change, so it is important to update the memory with new information each time it is reactivated in order to adjust the response in the future. Recent researches indicate that memory may undergo a dynamic process that could work as an updating mechanism. This process which is called reconsolidation involves destabilization of the memory after it is reactivated, followed by restabilization. Recently, it has been demonstrated that the initial destabilization process of reconsolidation requires protein degradation. Using protein degradation inhibition as a method to block reconsolidation, recent researches suggest that reconsolidation, especially the protein degradation-dependent destabilization process is necessary for memory reorganization.
摘要
记忆是由过去的经历形成的一种参考，用于应对当前的情况。然而，世界是动态的，情况会发生变化，因此每次记忆重新激活时用新信息更新记忆很重要，以便在未来调整反应。最近的研究表明，记忆可能经历一个动态过程，该过程可作为一种更新机制。这个被称为重新巩固的过程包括记忆重新激活后使其不稳定，随后再重新稳定。最近，已经证明重新巩固的初始不稳定过程需要蛋白质降解。利用蛋白质降解抑制作为阻断重新巩固的方法，最近的研究表明，重新巩固，尤其是依赖蛋白质降解的不稳定过程对于记忆重组是必要的。
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