间歇 IL-2 治疗对 HIV-1 感染患者肠道中 CD4 T 细胞的影响。
The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients.
机构信息
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
J Acquir Immune Defic Syndr. 2011 Apr;56(4):340-3. doi: 10.1097/QAI.0b013e31820bf84c.
Abstract
We sought to determine the effects of interleukin-2 administered in combination with antiretroviral therapy (ART) on CD4+ T cells in the gut. Lymphocytes from whole blood, colon, and terminal ileum of HIV-infected adults treated with interleukin-2 and ART or ART alone were examined. There were no differences between groups in the proportion of CD4+ T cells or in expression of CD25 or Ki67 by CD4+ T cells in the gut. Although IL-2 administration leads to expansion of peripheral blood CD4+ T cells, there is no alteration in the proportion or activation of CD4+ T cells in the gut mucosa.
摘要
我们旨在研究白细胞介素-2 联合抗逆转录病毒疗法（ART）对肠道中 CD4+T 细胞的影响。我们检测了接受白细胞介素-2 和 ART 联合治疗或仅接受 ART 治疗的 HIV 感染成年人的全血、结肠和回肠末端的淋巴细胞。各组间 CD4+T 细胞的比例以及 CD4+T 细胞上 CD25 或 Ki67 的表达均无差异。尽管白细胞介素-2 的给药会导致外周血 CD4+T 细胞的扩增，但肠道黏膜中 CD4+T 细胞的比例或活化状态并无改变。
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