Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Acta Ophthalmol. 2011 Jun;89(4):e336-43. doi: 10.1111/j.1755-3768.2010.02062.x. Epub 2011 Mar 4.
To describe risk factors associated with diabetic retinopathy (DR) in a population-based sample of rural Chinese with type 2 diabetes.
The Handan Eye Study is a population-based cross-sectional study surveyed 6830 Chinese people aged 30+ years from 13 randomly selected villages in 2006-2007. All participants underwent a standardized interview and extensive examinations including ophthalmologic and systemic conditions. Diabetic retinopathy was graded from fundus photographs according to the modified Early Treatment Diabetic Retinopathy Study classification system. Logistic regression models were used to assess risk factors associated with DR.
Of 7577 eligible persons, 6830 (90.4%) participated, of which 5597 (81.9%) had fasting plasma glucose (FPG) data. There were 387 (6.9%) participants with diabetes, and 368 (95.1%) had gradable fundus photographs. The age-standardized prevalence of DR was 43.1%. In multivariable-adjusted logistic regression models for all diabetic participants, independent risk factors for DR were longer duration of diabetes (odds ratio [OR] 3.07, 95% confidence interval [CI] 1.94, 4.85, per 5 years of duration), higher FPG levels (OR 1.17; 95% CI: 1.08, 1.27, per mmol/l increase) and higher systolic blood pressure (OR 1.22; 95% CI: 1.08, 1.37, per 10 mmHg increase). For newly diagnosed diabetes, the only significant factor of DR was higher FPG levels (OR 1.17; 95% CI: 1.05, 1.29, per mmol/l increase).
In rural Chinese persons with diabetes, longer diabetes duration, hyperglycaemia and elevated blood pressure are risk factors for DR. These findings underscore the importance of controlling classic risk factors for DR in developing countries, where diabetes prevalence is increasing.
描述与中国农村 2 型糖尿病患者中糖尿病视网膜病变（DR）相关的风险因素。
邯鄲眼研究是一项基于人群的横断面研究，于 2006 年至 2007 年对来自 13 个随机选择的村庄的 6830 名 30 岁以上的中国人进行了调查。所有参与者都接受了标准化的访谈和广泛的检查，包括眼科和全身状况。糖尿病视网膜病变根据改良的早期糖尿病视网膜病变研究分类系统从眼底照片进行分级。Logistic 回归模型用于评估与 DR 相关的风险因素。
在 7577 名合格人员中，有 6830 人（90.4%）参加了研究，其中 5597 人（81.9%）有空腹血糖（FPG）数据。有 387 名（6.9%）参与者患有糖尿病，有 368 名（95.1%）有可分级的眼底照片。DR 的年龄标准化患病率为 43.1%。在所有糖尿病患者的多变量调整 logistic 回归模型中，DR 的独立危险因素是糖尿病病程较长（比值比 [OR] 3.07，95%置信区间 [CI] 1.94，4.85，每增加 5 年）、FPG 水平较高（OR 1.17；95%CI：1.08，1.27，每增加 1mmol/l）和收缩压较高（OR 1.22；95%CI：1.08，1.37，每增加 10mmHg）。对于新诊断的糖尿病，DR 的唯一显著因素是较高的 FPG 水平（OR 1.17；95%CI：1.05，1.29，每增加 1mmol/l）。
在中国农村的糖尿病患者中，糖尿病病程较长、高血糖和血压升高是 DR 的危险因素。这些发现强调了在糖尿病患病率不断上升的发展中国家控制 DR 经典危险因素的重要性。
