National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Mar Drugs. 2010 Dec 6;8(12):2936-45. doi: 10.3390/md8122936.
Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
从印度尼西亚八放珊瑚 Cladiella sp. 中分离得到两个新的 eunicellin 型二萜化合物 cladielloides A(1)和 B(2)，它们的结构中均含有 2-羟基丁酰氧基。通过波谱方法阐明了 eunicellin 1 和 2 的结构。cladielloide B(2)对 CCRF-CEM 肿瘤细胞具有中等细胞毒性，并且该化合物对人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放具有显著抑制作用。
