Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan.
Mar Drugs. 2012 Jun;10(6):1203-1211. doi: 10.3390/md10061203. Epub 2012 May 25.
Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
从软珊瑚 Klyxum simplex 中分离得到了四个新的基于 eunicellin 的二萜类化合物， simplexins P-S（1-4）和已知化合物 simplexin A（5）。根据广泛的光谱分析，特别是 1D 和 2D NMR 实验，确定了新代谢产物的结构。化合物 1 和 3-5 对一组有限的癌细胞系表现出细胞毒性，其中 3 是最具细胞毒性的。
