Van Kuijk F J, Holte L L, Dratz E A
Chemistry Department, Montana State University, Bozeman 59717.
Biochim Biophys Acta. 1990 Mar 12;1043(1):116-8. doi: 10.1016/0005-2760(90)90118-h.
4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n - 6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.
4-羟基壬烯醛和4-羟基己烯醛是脂质过氧化产生的具有高生物活性的细胞毒性醛类产物。n-6脂肪酸的过氧化产生4-羟基壬烯醛，但4-羟基己烯醛的来源尚不确定。我们现在提供证据表明，4-羟基己烯醛是由组织中最丰富的n-3脂肪酸二十二碳六烯酸氧化产生的。
