鲍曼不动杆菌中对广谱头孢菌素具有增强活性的超广谱β-内酰胺酶 PER-7。
PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii.
机构信息
Service de Bactériologie-Virologie-Hygiène, INSERM U914, Hôpital de Bicêtre, 78 Rue de Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2424-7. doi: 10.1128/AAC.01795-10. Epub 2011 Mar 7.
Abstract
Acinetobacter baumannii isolate AP2 was recovered from a bronchial lavage sample of a patient hospitalized in Paris, France. A. baumannii AP2 was resistant to all β-lactams, including carbapenems, and expressed the extended-spectrum β-lactamase (ESBL) PER-7, which differs from PER-1 by 4 amino acid substitutions. Compared to PER-1, PER-7 possessed higher-level hydrolytic activities against cephalosporins and aztreonam. The blaPER-7 gene was chromosomally located and associated with a mosaic class 1 integron structure. Additionally, isolate AP2 expressed the carbapenem-hydrolyzing oxacillinase OXA-23 and the 16S RNA methylase ArmA, conferring high-level resistance to aminoglycosides.
摘要
鲍曼不动杆菌分离株 AP2 从一名在法国巴黎住院的患者的支气管灌洗样本中分离得到。AP2 对所有β-内酰胺类抗生素（包括碳青霉烯类）均具有耐药性，并表达了超广谱β-内酰胺酶（ESBL）PER-7，该酶与 PER-1 相比有 4 个氨基酸取代。与 PER-1 相比，PER-7 对头孢菌素类和氨曲南具有更高的水解活性。blaPER-7 基因位于染色体上，并与镶嵌式 class 1 整合子结构相关。此外，分离株 AP2 还表达了碳青霉烯水解的 oxacillinase OXA-23 和 16S RNA 甲基化酶 ArmA，对氨基糖苷类药物具有高水平的耐药性。
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