恒河猴感染猴痘病毒的新型呼吸道感染模型。
A novel respiratory model of infection with monkeypox virus in cynomolgus macaques.
机构信息
United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Virology Division, Viral Therapeutics Branch, 903Q, Fort Detrick, MD 21702-5011, USA.
出版信息
J Virol. 2011 May;85(10):4898-909. doi: 10.1128/JVI.02525-10. Epub 2011 Mar 9.
Abstract
Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.
摘要
天花，即引起天花的病原体，以及相关的猴痘病毒，都是选择剂，如果被故意释放，将引起公众恐慌和社会混乱。出于这个原因，研究仍在动物模型和治疗方法的开发领域继续进行。正痘病毒在宿主特异性方面表现出广泛的差异，这使得开发准确的动物模型变得困难。在本文中，我们展示了一种新的呼吸道感染技术，该技术导致非人类灵长类动物出现“典型”的正痘疾病，使研究领域更接近更好的动物模型。
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本文引用的文献
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Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo.刚果民主共和国停止天花疫苗接种活动 30 年后，人类猴痘发病率大幅上升。
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Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.抗病毒药物ST-246可保护非人类灵长类动物免受天花病毒或猴痘病毒的攻击。
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Smallpox and pan-orthopox virus detection by real-time 3'-minor groove binder TaqMan assays on the roche LightCycler and the Cepheid smart Cycler platforms.通过罗氏LightCycler和赛沛智能循环仪平台上的实时3'-小沟结合物TaqMan分析法检测天花和泛正痘病毒
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Update: multistate outbreak of monkeypox--Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003.最新消息：2003年伊利诺伊州、印第安纳州、堪萨斯州、密苏里州、俄亥俄州和威斯康星州的多州猴痘疫情
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