机械因素在干细胞命运决定中的作用。
Role of mechanical factors in fate decisions of stem cells.
机构信息
Department of Cell & Developmental Biology & Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Regen Med. 2011 Mar;6(2):229-40. doi: 10.2217/rme.11.2.
Abstract
Stem cells derived from adult tissues or from the inner cell mass of blastocyst-stage embryos can self-renew in culture and have the remarkable potential to undergo lineage-specific differentiation. Extensive studies have been devoted to achieving a better understanding of the soluble factors and the mechanism(s) by which they regulate the fate decisions of these cells, but it is only recently that a critical role has been revealed for physical and mechanical factors in controlling self-renewal and lineage specification. This review summarizes selected aspects of current work on stem cell mechanics with an emphasis on the influence of matrix stiffness, surface topography, cell shape and mechanical forces on the fate determination of mesenchymal stem cells and embryonic stem cells.
摘要
从成体组织或囊胚期胚胎的内细胞团中分离得到的干细胞在培养中能够自我更新，并具有显著的向特定谱系分化的潜能。大量研究致力于更好地理解可溶性因子及其调控这些细胞命运决定的机制，但直到最近，物理和机械因素在控制自我更新和谱系特化中的关键作用才被揭示出来。本文综述了干细胞力学研究的部分进展，重点讨论了基质硬度、表面形貌、细胞形状和机械力对间充质干细胞和胚胎干细胞命运决定的影响。
相似文献
1
Role of mechanical factors in fate decisions of stem cells.机械因素在干细胞命运决定中的作用。
Regen Med. 2011 Mar;6(2):229-40. doi: 10.2217/rme.11.2.
2
Controlling self-renewal and differentiation of stem cells via mechanical cues.通过机械信号控制干细胞的自我更新和分化。
J Biomed Biotechnol. 2012;2012:797410. doi: 10.1155/2012/797410. Epub 2012 Oct 2.
3
[Research status of mechanical stimulation of stem cells differentiation in stem cells microenvironment].[干细胞微环境中机械刺激对干细胞分化的研究现状]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2014 Jan;28(1):100-4.
4
Understanding the extracellular forces that determine cell fate and maintenance.了解决定细胞命运和维持的细胞外力量。
Development. 2017 Dec 1;144(23):4261-4270. doi: 10.1242/dev.158469.
5
A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions.机械转导的数学模型揭示了机械记忆如何调节间充质干细胞的命运决定。
BMC Syst Biol. 2017 May 16;11(1):55. doi: 10.1186/s12918-017-0429-x.
6
Biophysics and dynamics of natural and engineered stem cell microenvironments.自然和工程化干细胞微环境的生物物理和动力学。
Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb;2(1):49-64. doi: 10.1002/wsbm.46.
7
Inhibition of human embryonic stem cell differentiation by mechanical strain.机械应变对人胚胎干细胞分化的抑制作用。
J Cell Physiol. 2006 Jan;206(1):126-37. doi: 10.1002/jcp.20441.
8
Chemical and physical properties of regenerative medicine materials controlling stem cell fate.再生医学材料的化学和物理性质控制干细胞命运。
Ann Med. 2012 Nov;44(7):635-50. doi: 10.3109/07853890.2011.573805. Epub 2011 May 13.
9
Guidance of stem cell fate on 2D patterned surfaces.二维图案化表面上干细胞命运的调控。
Biomaterials. 2012 Oct;33(28):6626-33. doi: 10.1016/j.biomaterials.2012.05.070. Epub 2012 Jun 28.
10
Biophysical signals controlling cell fate decisions: how do stem cells really feel?生物物理信号控制细胞命运决定：干细胞到底是如何感知的？
Int J Biochem Cell Biol. 2012 Dec;44(12):2233-7. doi: 10.1016/j.biocel.2012.09.003. Epub 2012 Sep 12.
引用本文的文献
1
Towards a Comprehensive Framework for Made-to-Measure Alginate Scaffolds for Tissue Engineering Using Numerical Simulation.利用数值模拟建立用于组织工程的定制藻酸盐支架综合框架。
Gels. 2025 Mar 7;11(3):185. doi: 10.3390/gels11030185.
2
Advances in Shear Stress Stimulation of Stem Cells: A Review of the Last Three Decades.干细胞剪切应力刺激的研究进展：过去三十年综述
Biomedicines. 2024 Aug 29;12(9):1963. doi: 10.3390/biomedicines12091963.
3
Directed Differentiation of Adipose-Derived Stem Cells Using Imprinted Cell-Like Topographies as a Growth Factor-Free Approach.使用印记细胞样拓扑结构作为无生长因子方法对脂肪来源干细胞进行定向分化
Stem Cell Rev Rep. 2024 Oct;20(7):1752-1781. doi: 10.1007/s12015-024-10767-7. Epub 2024 Jul 27.
4
OctoShaker: A versatile robotic biomechanical agitator for cellular and organoid research.八爪鱼摇床：一种多功能的机器人生物力学搅拌器，用于细胞和类器官研究。
Rev Sci Instrum. 2023 Dec 1;94(12). doi: 10.1063/5.0174526.
5
Effect of whole body vibration therapy in the rat model of steroid-induced osteonecrosis of the femoral head.全身振动疗法对类固醇诱导的大鼠股骨头坏死模型的影响。
Front Cell Dev Biol. 2023 Oct 9;11:1251634. doi: 10.3389/fcell.2023.1251634. eCollection 2023.
6
Altered Mesenchymal Stem Cells Mechanotransduction from Oxidized Collagen: Morphological and Biophysical Observations.氧化胶原改变间充质干细胞的力学转导：形态和生物物理观察。
Int J Mol Sci. 2023 Feb 11;24(4):3635. doi: 10.3390/ijms24043635.
7
3D printing a biocompatible elastomer for modeling muscle regeneration after volumetric muscle loss.3D 打印一种生物相容性弹性体，用于模拟体积缺失性肌肉损失后的肌肉再生。
Biomater Adv. 2022 Nov;142:213171. doi: 10.1016/j.bioadv.2022.213171. Epub 2022 Oct 24.
8
Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis.细胞外囊泡在骨关节炎发病机制、诊断和治疗中的突破。
Bioact Mater. 2022 Oct 20;22:423-452. doi: 10.1016/j.bioactmat.2022.10.012. eCollection 2023 Apr.
9
The potential therapeutic role of extracellular vesicles in osteoarthritis.细胞外囊泡在骨关节炎中的潜在治疗作用。
Front Bioeng Biotechnol. 2022 Sep 16;10:1022368. doi: 10.3389/fbioe.2022.1022368. eCollection 2022.
10
Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche.通过黏附分子的机械转导：在调节干细胞微环境中的新作用。
Front Cell Dev Biol. 2022 Sep 12;10:966662. doi: 10.3389/fcell.2022.966662. eCollection 2022.
本文引用的文献
1
Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions.软基质通过下调细胞-基质牵引力促进胚胎干细胞的均匀自我更新。
PLoS One. 2010 Dec 13;5(12):e15655. doi: 10.1371/journal.pone.0015655.
2
Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.综合生化和机械信号调节多方面的人类胚胎干细胞功能。
J Cell Biol. 2010 Nov 1;191(3):631-44. doi: 10.1083/jcb.201006094. Epub 2010 Oct 25.
3
4
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells.肌动球蛋白收缩性导致分离的人胚胎干细胞活力降低。
Cell Stem Cell. 2010 Aug 6;7(2):240-8. doi: 10.1016/j.stem.2010.06.017.
5
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.诱导人多能干细胞凋亡的分子通路和细胞状态。
Cell Stem Cell. 2010 Aug 6;7(2):225-39. doi: 10.1016/j.stem.2010.06.018.
6
Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture.基质弹性调节培养中的骨骼肌干细胞自我更新。
Science. 2010 Aug 27;329(5995):1078-81. doi: 10.1126/science.1191035. Epub 2010 Jul 15.
7
Embryonic stem cells do not stiffen on rigid substrates.胚胎干细胞在刚性基底上不会变硬。
Biophys J. 2010 Jul 21;99(2):L19-21. doi: 10.1016/j.bpj.2010.04.057.
8
Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis.中性粒细胞趋化过程中牵引力的时空组织、调节和功能。
Blood. 2010 Oct 28;116(17):3297-310. doi: 10.1182/blood-2009-12-260851. Epub 2010 Jul 8.
9
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.测量黏着斑蛋白上的机械张力揭示了黏着斑动态的调控机制。
Nature. 2010 Jul 8;466(7303):263-6. doi: 10.1038/nature09198.
10
Optimal matrix rigidity for stress fiber polarization in stem cells.干细胞中应力纤维极化的最佳基质刚度
Nat Phys. 2010 Jun 1;6(6):468-473. doi: 10.1038/nphys1613.
Zotero 插件