莱耶尔病毒的基因组和系统进化特征分析，这是一种在澳大利亚北部分离到的新型正布尼亚病毒。
Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia.
机构信息
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
J Gen Virol. 2011 Jul;92(Pt 7):1676-1687. doi: 10.1099/vir.0.028308-0. Epub 2011 Mar 14.
Abstract
Leanyer virus (LEAV), currently classified as a member of the genus Orthobunyavirus, in the family Bunyaviridae, was originally isolated from a pool of Anopheles meraukensis mosquitoes, collected at Leanyer, Northern Territory, Australia in 1974. When it failed to react in serological tests with antisera from other known viruses, full-length genomic sequencing was pursued to determine the relationship of LEAV to other orthobunyavirus species. Genetic and serological characterization confirmed its antigenic distance from other orthobunyaviruses, including to its closest genetic neighbours, the Simbu group viruses, suggesting that it may represent a new antigenic complex.
摘要
利耶尔病毒（LEAV），目前被归类为布尼亚病毒科正布尼亚病毒属的一员，最初是从 1974 年在澳大利亚北领地的利耶尔采集的一群按蚊中分离出来的。当它在血清学测试中与来自其他已知病毒的抗血清没有反应时，进行了全长基因组测序，以确定 LEAV 与其他正布尼亚病毒种的关系。遗传和血清学特征确定了它与其他正布尼亚病毒的抗原距离，包括与它最接近的遗传邻居辛布组病毒，这表明它可能代表一个新的抗原复合物。
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