Institut Pasteur, Unit of Genetics and Genomics of Insect Vectors, Department of Parasites and Insect Vectors, 28 rue du Docteur Roux, 75015 Paris, France.
CNRS, Unit of Evolutionary Genomics, Modeling and Health (UMR2000), 28 rue du Docteur Roux, 75015 Paris, France.
Viruses. 2018 Apr 25;10(5):222. doi: 10.3390/v10050222.
mosquitoes are vectors of human malaria, but they also harbor viruses, collectively termed the virome. The virome is relatively poorly studied, and the number and function of viruses are unknown. Only the o'nyong-nyong arbovirus (ONNV) is known to be consistently transmitted to vertebrates by mosquitoes. A systematic literature review searched four databases: PubMed, Web of Science, Scopus, and Lissa. In addition, online and print resources were searched manually. The searches yielded 259 records. After screening for eligibility criteria, we found at least 51 viruses reported in , including viruses with potential to cause febrile disease if transmitted to humans or other vertebrates. Studies to date have not provided evidence that consistently transmit and maintain arboviruses other than ONNV. However, anthropophilic vectors of malaria are constantly exposed to arboviruses in human bloodmeals. It is possible that in malaria-endemic zones, febrile symptoms may be commonly misdiagnosed. It is also possible that anophelines may be inherently less competent arbovirus vectors than culicines, but if true, the biological basis would warrant further study. This systematic review contributes a context to characterize the biology, knowledge gaps, and potential public health risk of viruses.
蚊子是人类疟疾的载体，但它们也携带病毒，统称为病毒组。病毒组的研究相对较少，病毒的数量和功能尚不清楚。只有奥尼永永虫媒病毒（ONNV）被已知通过蚊子持续传播给脊椎动物。一项系统文献综述在四个数据库中进行：PubMed、Web of Science、Scopus 和 Lissa。此外，还通过在线和印刷资源进行了手动搜索。搜索共产生了 259 条记录。经过筛选符合入选标准后，我们发现至少有 51 种病毒在 中报告，包括如果传播给人类或其他脊椎动物，可能会引起发热疾病的病毒。迄今为止的研究并未提供证据表明 会持续传播和维持除 ONNV 以外的虫媒病毒。然而，疟疾的嗜人媒介蚊子经常在人类的血餐中接触虫媒病毒。在疟疾流行地区，发热症状可能经常被误诊为常见情况。也有可能是按蚊作为虫媒病毒的载体不如库蚊有效，但如果属实，其生物学基础将需要进一步研究。这项系统综述为描述 病毒的生物学、知识空白和潜在公共卫生风险提供了背景。
