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Specific cytotoxic effect of neocarzinostatin conjugated to monoclonal antibody A7 on human pancreatic carcinoma.

作者信息

Otsuji E, Takahashi T, Yamaguchi T, Yamaguchi N, Imanishi J

机构信息

First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.

出版信息

Gastroenterol Jpn. 1990 Apr;25(2):244-8. doi: 10.1007/BF02776823.

DOI:10.1007/BF02776823
PMID:2140808
Abstract

The anti-cancer drug neocarzinostatin (NCS) was bound covalently to the monoclonal antibody A7 to form the conjugate A7-NCS. This antibody was produced by fusing the spleen cells of a mouse immunized against human colonic carcinoma with murine myeloma cells and reacts with a high percentage of human pancreatic carcinoma cell lines and with no normal human pancreas tissue by immunoperoxidase staining. The cytotoxic effect of A7-NCS was tested by measuring the inhibition of 3H-thymidine incorporation into human pancreatic carcinoma cells. The A7-NCS was approximately 2.7 times as effective as free NCS against human pancreatic carcinoma cells which reacted with the monoclonal antibody A7. A7-NCS had almost the same cytotoxicity a free NCS on human pancreatic carcinoma cells which did not react with the monoclonal antibody A7. A7-NCS appeared to be potentially useful as a conjugate for immunotargeting chemotherapy against pancreatic carcinoma.

摘要

相似文献

1
Specific cytotoxic effect of neocarzinostatin conjugated to monoclonal antibody A7 on human pancreatic carcinoma.
Gastroenterol Jpn. 1990 Apr;25(2):244-8. doi: 10.1007/BF02776823.
2
Antitumor effect of neocarzinostatin conjugated to human/mouse chimeric Fab fragments of the monoclonal antibody A7 on human pancreatic carcinoma.与单克隆抗体A7的人/鼠嵌合Fab片段偶联的新制癌菌素对人胰腺癌的抗肿瘤作用。
J Surg Oncol. 1994 Dec;57(4):230-4. doi: 10.1002/jso.2930570405.
3
[Missile therapy of colorectal and pancreatic cancers--clinical trial of monoclonal antibody, A7-NCS, in 73 patients with colorectal and pancreatic cancers].
Gan To Kagaku Ryoho. 1990 Jun;17(6):1111-9.
4
Intratumoral administration of neocarzinostatin conjugated to monoclonal antibody A7 in a model of pancreatic cancer.在胰腺癌模型中，瘤内注射与单克隆抗体A7偶联的新制癌菌素。
J Surg Oncol. 1993 Aug;53(4):215-9. doi: 10.1002/jso.2930530405.
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Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma.单克隆抗体-药物偶联物在结直肠癌免疫靶向化疗中的临床应用
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6
[Clinical application of monoclonal antibody-drug conjugates in colorectal carcinoma].
Gan To Kagaku Ryoho. 1988 May;15(5):1702-9.
7
[Missile therapy using monoclonal antibody drug conjugates in colorectal carcinoma].
Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 2):931-7.
8
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9
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10
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Eur J Surg Oncol. 1995 Feb;21(1):61-5. doi: 10.1016/s0748-7983(05)80070-8.

引用本文的文献

1
Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.抗生物素蛋白给药后与生物素化嵌合单克隆抗体Fab片段偶联的新制癌菌素的分布。
Br J Cancer. 1996 Aug;74(4):597-602. doi: 10.1038/bjc.1996.407.
2
Effects of neocarzinostatin-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts.新制癌菌素-嵌合Fab缀合物对人胰腺癌异种移植瘤生长的影响。
Br J Cancer. 1996 May;73(10):1178-82. doi: 10.1038/bjc.1996.227.
3
Enhanced tumor localization of radiolabeled Fab fragments of monoclonal antibody A7 in nude mice bearing human pancreatic carcinoma xenografts.

本文引用的文献

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Demographic characteristics of cancer of the pancreas: mortality, incidence, and survival.胰腺癌的人口统计学特征：死亡率、发病率和生存率。
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In vitro reactivity and in vivo biodistribution of the monoclonal antibody A7 using human gastric carcinoma cell lines.利用人胃癌细胞系对单克隆抗体A7进行体外反应性和体内生物分布研究。
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Biodistribution of neocarzinostatin conjugated to chimeric Fab fragments of the monoclonal antibody A7 in nude mice bearing human pancreatic cancer xenografts.新制癌菌素与单克隆抗体A7的嵌合Fab片段偶联物在携带人胰腺癌异种移植物的裸鼠中的生物分布。
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Fluorophotometric enzyme immunoassay of neocarzinostatin using peroxidase as a label.以过氧化物酶为标记物的新制癌菌素的荧光光度酶免疫测定法。
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6
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Biochemistry. 1980 Apr 29;19(9):1767-73. doi: 10.1021/bi00550a007.
7
Chemotherapy for bladder cancer with neocarzinostatin: evaluation of systemic administration.用新制癌菌素治疗膀胱癌：全身给药的评估
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Neocarzinostatin in cancer chemotherapy (review).新制癌菌素在癌症化疗中的应用（综述）
Anticancer Res. 1981;1(3):175-86.
9
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.抗生物素蛋白-生物素-过氧化物酶复合物（ABC）在免疫过氧化物酶技术中的应用：ABC法与未标记抗体（PAP）法的比较。
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10
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Nouv Rev Fr Hematol. 1973 Jul-Aug;13(4):445-51.