Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, 2-22, Yamadaoka, 565, Suita, Japan.
Environ Health Prev Med. 1996 Jul;1(2):76-9. doi: 10.1007/BF02931194.
To determine whether acute mental stress alters the composition of peripheral blood cells or components of the immune system, we determined blood cell counts and leukocyte differential counts, and examined lymphocyte subsets, before, during, and after 10 min. of mental arithmetic in 20 healthy female students. During mental stress the absolute number of leukocytes, lymphocytes, CD8+ cells, and CD16+ cells increased significantly, and the rate of CD8+ cell increase was higher than CD4+ cell increase. Therefore the CD4+/CD8+ ratio decreased significantly during mental stress. Erythrocyte counts, hemoglobin concentrations and packed cell volumes remained unchanged during and after mental stress. These results demonstrate that acute mental stress is associated mainly with rapid peripheral blood lymphocyte changes, including the release of CD8+ and CD 16+ cells into circulation. The absence of significant increases in erythrocyte counts, hemoglobin concentrations, and packed cell volumes during stress indicates that changes in lymphocyte composition cannot be explained by the hemoconcentration. Thus, acute mental stress has a detectable influence on peripheral blood cell counts and the immune system.
为了确定急性心理应激是否会改变外周血细胞或免疫系统的组成成分,我们在 20 名健康女性学生进行 10 分钟心算前后,测定了血细胞计数和白细胞分类计数,并检查了淋巴细胞亚群。在心理应激期间,白细胞、淋巴细胞、CD8+细胞和 CD16+细胞的绝对值显著增加,且 CD8+细胞的增加速度高于 CD4+细胞。因此,在心理应激期间 CD4+/CD8+比值显著降低。红细胞计数、血红蛋白浓度和红细胞压积在心理应激期间和之后保持不变。这些结果表明,急性心理应激主要与外周血淋巴细胞的快速变化有关,包括 CD8+和 CD16+细胞向循环系统的释放。在应激期间红细胞计数、血红蛋白浓度和红细胞压积没有显著增加表明,淋巴细胞组成的变化不能用血液浓缩来解释。因此,急性心理应激对外周血细胞计数和免疫系统有明显影响。