语境中的 RNA 世界。
The RNA worlds in context.
机构信息
Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309-0215, USA.
出版信息
Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a006742. doi: 10.1101/cshperspect.a006742.
There are two RNA worlds. The first is the primordial RNA world, a hypothetical era when RNA served as both information and function, both genotype and phenotype. The second RNA world is that of today's biological systems, where RNA plays active roles in catalyzing biochemical reactions, in translating mRNA into proteins, in regulating gene expression, and in the constant battle between infectious agents trying to subvert host defense systems and host cells protecting themselves from infection. This second RNA world is not at all hypothetical, and although we do not have all the answers about how it works, we have the tools to continue our interrogation of this world and refine our understanding. The fun comes when we try to use our secure knowledge of the modern RNA world to infer what the primordial RNA world might have looked like.
存在两个 RNA 世界。第一个是原始 RNA 世界，这是一个假设的时代，在这个时代，RNA 既充当信息又充当功能，既是基因型又是表型。第二个 RNA 世界是当今生物系统的世界，在这个世界中，RNA 在催化生化反应、将 mRNA 翻译成蛋白质、调节基因表达以及在感染性因子试图颠覆宿主防御系统和宿主细胞保护自身免受感染的持续斗争中发挥着积极作用。第二个 RNA 世界并非完全是假设的，尽管我们还没有关于它如何运作的所有答案，但我们有工具继续研究这个世界并完善我们的理解。当我们试图利用我们对现代 RNA 世界的可靠知识来推断原始 RNA 世界可能是什么样子时，乐趣就来了。
Zotero 插件