MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Department of Medical Biophysics and Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cell Metab. 2011 Apr 6;13(4):361-366. doi: 10.1016/j.cmet.2011.03.010.
Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
活性氧不仅是在病理学中引起氧化损伤的有害剂，它们在多种生物现象中也具有重要的调节作用。这种更为微妙的观点的相对较新的发展，对生物医学研究界提出了一个挑战，即如何最好地评估生物系统中活性氧和氧化损伤的意义。在解决这些问题方面正在取得相当大的进展，在这里我们为那些考虑在该领域进行研究的人调查了一些最新的进展。
